Alan Kueichieh Chang

Profile

Dr. Alan K. Chang is a foreign teacher who joined the College of Life and Environmental Sciences at Wenzhou University in 2016 as a full-time teaching staff and a specially appointed professor. Dr. Chang is from Australia, and he obtained his Ph.D. degree from the University of Queensland. After graduation, he continued to work as a full-time researcher in Australia. He later went to South Korea, America, and other cities in China where he continued to pursue his research and began teaching before coming to work at Wenzhou University. His previous research focused on the structural and functional studies of recombinant proteins from plants and bacteria. He has also collaborated with colleagues in other fields, including fermentation, the molecular mechanisms of cancer, and the biological effects of natural products with medicinal values. His research and collaboration with colleagues have led to the publication of numerous papers across different disciplines.

Here at Wenzhou University, Dr. Chang teaches zoology, biochemistry, cell biology, and molecular biology to international undergraduate students majoring in biotechnology, and scientific writing to both international undergraduate and local graduate students, as well as oral English and other forms of English writing to undergraduate and graduate students from different majors.

Besides teaching, Dr. Chang also works with Professor Yin Xueping in her research on the effects of cadmium on marine bivalves and the underlying mechanisms associated with cadmium-induced toxicity. So far, this research has led to the publication of several papers. His collaboration with former colleagues outside Wenzhou University has also led to a number of publications in recent years. Another important task in Dr. Chang’s work at Wenzhou University is to actively edit scientific papers written in English by teachers and graduate students within the college for publication in international scientific journals. Over the years, many of the papers that he has edited have been successfully published in different journals. Dr. Chang has extensive knowledge and first-hand experience in scientific writing through many years of editing work in this field. He believes that scientific writing and communication are a vital part of the training of students to become scientists. He has held seminars on scientific writing within the university and outside his classes so that more students could benefit from his knowledge and experience in scientific writing.

Apart from his teaching, scientific paper editing, and limited research activity, Dr. Chang also holds cultural discussion and exchange activities with local and foreign students and teachers from Wenzhou University, as well as Wenzhou Medical University and Wenzhou Kean University in his English Bridge program, which is part of the Luoshan Foreign Language Bridge program organized by Yuying Library at Wenzhou University. Dr. Chang believes that raising cultural awareness among students and teachers can provide a positive benefit to life under cross-cultural influences.

Dr Chang working in the lab                                                   Dr Chang with graduate students

Selected Publications

Chang A. K. & Duggleby R.G. (1997) Expression, purification and characterization of an Arabidopsis thaliana acetohydroxyacid synthase.  <span style="mso-spacerun:'yes';font-family:Calibri;mso-fareast-font-family:等线;color:#000000 Effects of deletions at the carboxyl terminus of Zymomonas mobilis pyruvate decarboxylase on the kinetic properties and substrate specificity. Chang A.K., Kim H.Y., Park J.E., Acharya P., Park I.S., Yoon S.M., You H.J., Hahm K.S., Park J.K., & Lee J.S. (2005) Vibrio vulnificus secretes a broad-specificity metalloprotease capable of interfering with blood homeostasis through prothrombin activation and fibrinolysis. .Li Q, Zhao X.Q, Chang A. K., Zhang Q.M, Bai F.W. (2012) Ethanol-induced yeast flocculation directed by the promoter of TPS1 encoding trehalose-6-phosphate synthase 1 for efficient ethanol production.

Xing X., Bi H., Chang A. K., Zang M., Wang M., Ao X., Li S., Pan  H., Guo Q., & Wu H. (2012) SUMOylation of AhR modulates its activity and stability through inhibiting its ubiquitination. Effect of replacing dietary fish meal with silkworm (Bombyx mori L) caterpillar meal on growth and non-specific immunity of sea cucumber Apostichopus japonicus (Selenka) Chang A. K. and Huijian Wu. (2012) The role of AIB1 in breast cancer (Review)

Li S., Wang M., Ao X., Chang A. K., Yang C., Zhao F., Bi H., Liu Y., Xiao L., & Wu H. (2013) CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-a.

He J., Wang Y., Chang A. K., Xu L., Wang N., Chong X., Li H., Zhang B., Jones G.W., & Song Y. (2014) Myricetin prevents fibrillogenesis of hen egg white lysozyme.  Sun Y., Chang A. K., Wen Z., Li Y., Du X., & Li S. (2014) Effect of replacing dietary fish meal with silkworm (Bombyx mori L) caterpillar meal on growth and non-specific immunity of sea cucumber Apostichopus japonicus (Selenka). Chong, X., Sun, L., Sun, Y., Chang, L., Chang, A. K., Lu, X., Zhou X., Liu J., Zhang B., Jones G. W., & He, J. (2017) Insights into the mechanism of how Morin suppresses amyloid fibrillation of hen egg white lysozyme. <span style="mso-spacerun:'yes';font-family:等线;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#000000 Effects of waterborne cadmium exposure on its internal distribution in Meretrix meretrix and detoxification by metallothionein and antioxidant enzymes. Liang X., Hu Y., Li J., Chang A. K., Tao X., Li Y., Liu W., Pi K., Yuan J. & Liang Z. (2020) Identification and pharmacokinetics of quinone reductase 2 inhibitors after oral administration of Garcinia mangostana L. extract in rat by LC–MS/MS.

Hu Y., Li J., Chang A. K., Li Y., Tao X., Liu W., Wang Z., Su W., Li Z., & Liang X. (2021) Screening and tissue distribution of protein tyrosine phosphatase 1B inhibitors in mice following oral administration of Garcinia mangostana L. ethanolic extract Food Chem. 357:129759.

Wang X., Banda J., Qi H., Chang A. K., Bwalya C., & Li X. (2022) Scarless wound healing: Current insights from the perspectives of TGF-β, KGF-1, and KGF-2 (Review).

Bai B., Yang Y., Wei J., Zheng Q., Wang M., Chang A. K., & Ying X. (2022) Cadmium-induced toxicity in Meretrix meretrix ovary is characterized by oxidative damage with changes in cell morphology and apoptosis-related factors

Li, J., Su, W., Pei, Y., Li H., Liu K., Ai J., Weng X., Fu H., Wang T., Chen L., Liang X., & Chang A. K. (2023) Ball milling extraction as a green and efficient approach for the extraction of sixteen xanthone-type QR-2 and PTP1B inhibitors from Garcinia mangostana L. pericarp. Food Anal. Methods https://doi.org/10.1007/s12161-023-02495-4